image: Sara Krulwich, nytimes
adding page while reading on the move – recommend via Maria…
ie: oh my… to 4700 ish… add sacks page
so much resonation w/last 7 yrs
I wondered whether systems in the brain concerned with the perception (or projection) of meaning, significance, and intentionality, systems underlying a sense of wonder and mysteriousness, systems for appreciation of the beauty of art and science, had lost their balance in schizophrenia, producing a mental world overcharged with intense emotion and distortions of reality. These systems had lost their middle ground, it seemed, so that any attempt to titrate them, damp them down, could tip the person from a pathologically heightened state to one of great dullness, a sort of mental death.
cure.. self-talk as data.. curiosity.. ness… waking us all up..
The Drug Enforcement Administration wanted me to fill out standardized inventories of symptoms and responses to the drug, but what was going on was so complex in both neurological and human terms that such inventories could not begin to accommodate the reality of what I was witnessing
Almost every day, there were fertile, exciting discussions about the unprecedented events unfolding before us, which demanded unprecedented approaches from us all.
oh.. the alive ness of change. of deep enough ness.
I knew that I had been given the rarest of opportunities; I knew that I had something important to say, but I saw no way of saying it, of being faithful to my experiences, without forfeiting medical “publishability” or acceptance among my colleagues.
I never use one adjective if six seem to me better and, in their cumulative effect, more incisive.
slash slash ish ness
I realized, too late, that there were whole sides to her which I had known nothing about
danger of a single story ness
Some of the patients, of course, did not want to be filmed, but most of them felt it was important to show themselves as human beings who had been forced to dwell in a deeply strange world
quiet enough to see/hear..
The chief staff psychologist said that a well-organized and successful behavior modification program had been set up and that I was undermining this by my notions of “play” not conditional on external rewards or punishment.
Ed.. us.. perpetuate\ing not us ness
I don’t have a Department. I am not in a Department. I am a gypsy, and survive—rather marginally and precariously
what is a lab.. ie: all of us.. not definable.. not capture able.. unless we want to go back to sleep/death..
and now to 4700 ish – much to add..
A whole new way of thinking seemed to ray out from Zeki’s work, and it set me thinking of the possible neural basis for consciousness in a way I had never considered before—and to realize that with our new powers of imaging the brain and our newly developed abilities to record the activity of individual neurons in living and conscious brains, we might be able to plot how and where all sorts of experiences are “constructed.” This was an exhilarating thought. I realized the vast leap which neurophysiology had made since my own student days in the early 1950s, when it was beyond our power, almost beyond imagination, to *record from individual nerve cells in the brain while an animal was conscious, perceiving, and acting.
he said he would love to meet mr i, who would be able to tell him exactly what he was seeing or not seeing, unlike th emonkeys he worked with..
ralph though always in deep physiological terms, while neurologists, myself included, often content ourselves w/the phenomenology of brain disease or damage, with little thought of the precise mechanism involved and no thought at all of the ultimate question of how experience and consciousness emerged from brain activity. … the relationship of brain and mind..
la jolla had become the neuroscience capital of the world by 1995
2011 – raph died, far too young from brain cancer, at the age of 52. i miss him deeply, but like so many of my friends’ and mentors’ his voice has become an integral part of my thinking.
never just me.. ness
in 53 while at oxford, i read watson and crick’s famos double helix letter….it was only in 1962 when crick camee to san fran … that i started to realize the vast implications of double helix. crick’s talk was not on the configuration of dna but on work he had been doing with the molecular biologist..sydney brenner to determine how the sequence of dna bases could specify the amino acid sequence in proteins.… but clearly crick has already moved on to other things… to great enterprises : understanding the origin and nature of life, and understanding the relation of brain an d mind – in particular, the biological basis of consciousness. did he have an inkling, when he spoke to us in 1962 that these would be the very subjects he himself would address in the years to come, once he had ‘dealt with’ molecular biology, or at least taken it to the stage where it could be delegated to others..?
thinking two loop ness
click .. wanted stories of how vision might be altered by brain damage or disease….. writing to him a few days later.. i said that the experience as ‘a little like sitting next to an intellectual nuclear reactor.. i never had a feeling of such *incandescence….
*first convo w/ dave.. and imagining/longing for convos w others.. to the – such – degree
in the few minutes of a migraine aura, a flickering of static
frozen images in place of their normal, continuous visual perception.. he asked me whether such ‘cinematic vision’ as i called it was ever a *permanent condition or one that could be elicited in a predictable way so that it could be investigate. (i said i did not know.)
*dead (asleep) ness.. can’t we… notice/observe/investigate alive ness..
Only in the actual writing did I come to see how color might indeed be a (cerebro-mental) construct.” I had spent most of my professional life wedded to notions of “naive realism,” regarding visual perceptions, for example, as mere transcriptions of retinal images; this “positivist” view was the dominant one in my Oxford days. But now, as I worked with Mr. I., this was giving way to a very different vision of the brain-mind, a vision of it as essentially constructive or creative. I added that I had now started to wonder whether all perceptual qualities, including the perception of motion, were similarly constructed by the brain.
… the case of the colorblind painter.. crick loved it.. his responses… five pages.. bursting with ideas and suggestions.. wild speculation..
Even though, as you stress in your letter, it is not strictly a scientific article, nevertheless it has aroused much interest among my colleagues and my scientific and philosophical friends here.
i was very excited to think that crick was opening our paper, our case, for discussion in this way. it gave me a deeper sense of science as a communal enterprise, of scientists as fraternal, international community, sharing and thinking on each other’s work, and crick himself as a sort of hub, in touch with everyone in this neuroscientific world. … of course the most interesting feature, crick wrote:
mr i’s loss of the subjective sense of color, together with its absence in his eidetic imagination and in his dreams. This clearly suggests that a crucial part of the apparatus needed for these latter two phenomena is also needed for color perception. At the same time, his memory for color names and color associations remained completely intact.
2 min video (and image above) – from ny times
his bearing witness is what he wants to be remembered for… to be in it himself
Oliver Sacks: On Robin Williams and the Brain (Feb 23, 1995) | Charlie Rose
i want to know what all of my patients experience… i want to dive in and experience myself if i can
the way in which the brain embodies the self
on big think.. a brain that can’t hear music
Leading the Mind: An Evening with Oliver Sacks (2007)
The essence of leadership is based on empowering individuals, organizations and societies to forgo the status quo and find new ways to solve complex challenges. Dr. Sacks will explore the mysteries of the mind based on his four-decade journey where he has encountered an unshakable human capacity in the face of seemingly insurmountable forces. In his newest book, *Musicophilia: Tales of Music and the Brain, Dr. Sacks investigates the power of music to move us, to heal and to haunt us.
on hold on overdrive – thanks library – musicophilia
4 min – on pinker – saying music is useless… i disagree. i think most of us have a real need for music…
7 min – absolute amusia – can’t recognize music
10 min – it’s not good to be accused…
12 min – how can you be deaf to music and nothing else… this is the state of amusia… there is like 30 parts of the brain involved w/ music
13 min – on hearing it was neurological (instead of fraud/emotional) … which made it morally ok
16 min – gotfried shlague – work on music on brain
please don’t photo me…distracting.. i prefer to be a voice..
18 min – even if people aren’t moving to music.. motor parts of brain working…. it’s not clear that any non human animal is moved in the same way
19 min – can’t look at a brain and say.. this is a brain of a writer/mathematician.. et al.. but you can look at a brain and say.. this is probably the brain of a musician.. even w/a naked eye… shows power of music and plasticity of brain... even a yr of intensive training will alter brain considerably…
20 min – once musical networks are set up.. they are very robust… and even in something like adv alzheimer’s disease… responding to music… stays almost till the end
24 min – he didn’t have facts.. but he had acts… procedural memory invested in primitive parts of brain… so those parts remain.. a treasure house.. a bank.. where all sorts of procedures can be locked away.. available for life….
actor.. very lost in daily life.. but repertoire all available.. look and feel virtually normal
memory will come like a rope let down from heaven… woody becomes himself in performance….
26 min – music therapy is crucial for many sorts of patients…
27 min – woody and emerson – i’ve lost all my faculties.. but i’m very well…
30 min – poet.. wh orden – quoting (?) – every disease is a musical problem and every cure is a musical solution… almost too pat to be true but seemed to nail it with these parkinsonians.. music substitutes for the basil ganglia.. for a little while..
31 min – restoring speech/language to people who have ephasia.. from strokes or whatever… many are mute… but can sing… shows.. language is still there… so can they dis embed it from the music… music made as great re organization of the brain
33 min – not so good power of music – all of us have tunes running through our head.. the tunes which play in ones head.. may be stimulated by sight/memory/mood… usually has some meaning.. or may go w/some activity.. ie: for me.. swimming.. i start counting then turns to strauss waltz… music is counting .. but counting unconsciously..
sometimes it’s mysterious and have to go to analyst to find out why it’s in your head..
35 min – our brains very disposed to music/musical imagery.. and sometimes this becomes pathological… looping…
37 min – getting trap inside the tune of a song… ie: his friend did for 10 days…
38 min – esp exploited in tv shows.. to hook people and render the brain helpless..
39 min – imagery can activate the brain in the same way as perception
40 min – today bombarded w/music everywhere.. can’t turn off your ears… i have mixed feelings about ipods… the power of it.. but the danger of the music being too load.. esp if being used to blot out the environment… ie: juvenile deafness… in ny 90% of people look as if hallucinating..
42 min – ear worms are universal.. has to do w/susceptibility of brain.. not rare.. musical hallucinations…
47 min – i think about 80-90% of people w/musical hallucinations have moderately severe deafness… will come on w/further loss of hearing.. analogy to visual hallucinations occur w/people losing sight.. or olfactory w/losing sense of smell… you can’t have a vacancy in the brain.. has to be filled w/something…
48 min – people get scared.. they are schizo.. but not the same…
50 min – i wonder w/ increasing deafness and all this noise around.. if we’ll be having more hallucinations..
some may have epileptic seizures produced by music
54 min – prior to 1970 nearly no music in neurology..
Honoring the life and work of Dr. Oliver Sacks, working to increase understanding of the brain and mind and to end the stigma of mental illness.
Oliver Wolf Sacks, CBE, FRCP (9 July 1933 – 30 August 2015) was a British neurologist, naturalist and author who spent his professional life in the United States. He felt that the brain was the “most incredible thing in the universe” and therefore important to study. He became widely known for writing best-selling case histories about his patients’ disorders, with some of his books adapted for film and stage.
Sacks was the author of numerous best-selling books, mostly collections of case studies of people with neurological disorders. His writings have been featured in a wide range of media; the New York Times called him a “poet laureate of contemporary medicine”, and “one of the great clinical writers of the twentieth century”. His books included a wealth of narrative detail about his experiences with patients, and how they coped with their conditions, often illuminating how the normal brain deals with perception, memory and individuality.
Awakenings (1973), an autobiographical account of his efforts to help people with encephalitis lethargicaregain proper neurological function, was adapted into the Academy Award-nominated film in 1990, starringRobin Williams and Robert De Niro.
as i finished Sacks’ book
Turns out there’s a guy with an IQ of 126 and 5% or 10% of normal brain mass rifters.com/crawl/?p=6116 something amazing can be learned here
On a somewhat less peer-reviewed note, VNBs also get routinely trotted out by religious nut jobs who cite them as evidence that a God-given soul must be doing all those things the uppity scientists keep attributing to the brain. ..
And yet, 126 IQ. Virtually no brain. In my darkest moments of doubt, I wondered if they might be right.
So on and off for the past twenty years, I’ve lain awake at night wondering how a brain the size of a poodle’s could kick my ass at advanced mathematics. I’ve wondered if these miracle freaks might actually have the same brain mass as the rest of us, but squeezed into a smaller, high-density volume by the pressure of all that cerebrospinal fluid (apparently the answer is: no). While I was writing Blindsight— having learned that cortical modules in the brains of autistic savants are relatively underconnected, forcing each to become more efficient— I wondered if some kind of network-isolation effect might be in play.
Now, it turns out the answer to that is: Maybe
The authors advocate research into “Computational models such as the small-world and scale-free network”— networks whose nodes are clustered into highly-interconnected “cliques”, while the cliques themselves are more sparsely connected one to another. De Oliveira et al suggest that they hold the secret to the resilience of the hydrocephalic brain. Such networks result in “higher dynamical complexity, lower wiring costs, and resilience to tissue insults.” This also seems reminiscent of those isolated hyper-efficient modules of autistic savants, which is unlikely to be a coincidence: networks from social to genetic to neural have all been described as “small-world”.
The point, though, is that under the right conditions, brain damage may paradoxically result in brain enhancement. Small-world, scale-free networking— focused, intensified, overclocked— might turbocharge a fragment of a brain into acting like the whole thing.
Maybe you don’t have to tweak genes or interface brains with computers to make the next great leap in cognitive evolution. Right now, right here in the real world, the cognitive function of brain tissue can be boosted— without engineering, without augmentation— by literal orders of magnitude. All it takes, apparently, is the right kind of stress.
on the move and Oliver via Maria.:
Encephalitis Lethargica Awakenings Oliver Sacks with text
he has drawn millions of people into worlds they might have shunned..
she said, i’ve been a spectator for the last 43 years..
i didn’t realize there would be a resurrection in the summer of 69.. or how grim it would be afterwards
a message of survival.. that one can go through and be in hell and yet survive.. as tough…funnly.. loving life.. even if no hope in ordinary sense..
starting around 1917.. sleeping sickness epidemic.. leaving almost 5 million people dead. in 1927 essentially disappeared.. although many institutions had to be built just to house all the living victims that were left permanently damaged…
awakenings trailer (w/robin):
via Maria – short film – unmoored, th elost mariner- inspires by Oliver’s the man who mistook his wife for a hat
“My work, my life, is all with the sick — but the sick and their sickness drives me to thoughts which, perhaps, I might otherwise not have,
“The Lost Mariner,” which Dr. Sacks opens with an epigraph from the great Spanish filmmaker Luis Buñuel:
You have to begin to lose your memory, if only in bits and pieces, to realize that memory is what makes our lives. Life without memory is no life at all… Our memory is our coherence, our reason, our feeling, even our action. Without it, we are nothing.
notes/highlights from musicophilia
Watch this and have a little cry. God knows, I did. The last ever interview with Oliver Sacks: ideas.ted.com/first-look-the…
The last ever interview with Dr Oliver Sacks
when people die.. they cannot be replaced.. each one unique
remembing oliver.. via maria
To commemorate this irreplaceable man, I asked artist Debbie Millman to create a piece of art illustrating the passage that captures not only the heart of that heartening story, but the spirit in which Dr. Sacks inhabited and exited our world.
image links to print
june 2016 – world science festival – Awakening the Mind: A Celebration of the Life and Work of Oliver Sacks
on @#‘ piano lessons at 75. he played everything staccato & forte. amazed at his perseverance w great physical obstacles
Now witnessing how music affects brain # #
how to reach people that seemed otherwise unreachable. (1995) music therapy to form dialogues – on @#work –
observation is a very important part of science. observers are the leaders. @#was a great observer. – @
he ( @# livestream.com/WorldScienceFe…) was open to being surprised –
i just fell in love w/way he sees world. he saw people in way increasingly counter by how seen today – @#on @
he ( @# livestream.com/WorldScienceFe…) had crazy eyes for seeing. he could consume all kinds of info easily.
big elephant in room whole life until made aware of @#‘s writings. reassured me i didn’t have to be ashamed –
he ( @# livestream.com/WorldScienceFe…)’s made observations others hadn’t seen –
his ( @#)’s whisper was: don’t miss this. the journey to death need not diminish our curiosity. patients do best research
we were friends because i have a disability. he ( @#) found interesting the uninteresting things in my life. –
how @#was able to take in any extraneous info
he ( @oliversacks) was definitely in love with water – swim coach #WSF16
1000s journals. rarely look at them. not written for others. form of talking to self. integral part of my mental life. @OliverSacks #WSF16
Oliver was able to expand the reach of the neighborhood, to include the excluded. – friends talking about
i love him.. and i don’t think i’m alone in that.. thank you
never seen a man getting closer and closer to death as his eyes got wider and wider open – @OliverSacks #WSF16
J Baldwin: poet as only one who knows what it’s like to be here – @#was that kind of poet. – @
Oliver Sacks’ last interview. Dig the sweet 1894 Bechstein grand piano—his dad’s—in bckgrnd vimeo.com/160629469
find own path, live own life..
Oliver Sacks on playing the piano: webofstories.com/play/oliver.sa…
can’t appreciate unless you play.. you can love/swoon.. but have to play to appreciate
#121 – oxford dictionary – for me the most coveted and desirable book in the world. I was to read the entire dictionary through when I went on to medical school, and I still like to take a volume off the shelf, now and then, for bedtime reading
love letters – from *insominiac city by bill hayes (@BillHayesNYC)
I just want to enjoy your nextness and nearness
Wouldn’t it be nice if we could dream together?
you create the need which you fill, the hunger you sate.
Over dinner, O talking about his late friend Gaj — Carleton Gajdusek, a Nobel laureate in medicine — with great excitement and conviction, comparing him to Goethe, of whom it was said, O tells me, “He had a nature. A nature.”
I thought I knew what O meant — O, who has always disliked being pigeonholed, typed, as simply one thing or another, doctor or writer, gay or not, Jewish or atheist, etc. — but I wasn’t completely sure and prodded him.
“A nature,” he repeated, as if that was the only way to say it. “He wasn’t this or that, fitted with so many labels, an ‘identity,’ like people today, but all aspects of him were of a piece — this is who he was, not what he was; a force of nature, I suppose.
I don’t so much fear death as I do wasting life
Every day, we may wake up and say, What’s the point? Why go on? And, there is really only one answer: To be alive. – bill
This @Radiolab story on @OliverSacks is everything. https://t.co/oqNc9UzKu6
Original Tweet: https://twitter.com/brainpicker/status/927618588789411841
Oliver died in 2015, but before he passed he and his partner Bill Hayes, in an effort to preserve some of Oliver’s thoughts on his work and his life, bought a little tape recorder. Over a year and half after Oliver’s death, Bill dug up the recorder and turned it on. Through snippets of conversation with Bill, and in moments Oliver recorded whispering to himself as he wrote, we get a peek inside the head, and the life, of one of the greatest science essayists of all time
8 min – here’s a man with huge vocab.. and everyday.. wanting to look up new words
14 min – we’d been together 6 yrs.. i knew him quite well.. yet i’d never seen him quite focused..
20 min – every mishearing is a surprising concoction..
21 min – my mishearings..
the animated mind of oliver sacks (doc).. 1 min clip: [https://www.youtube.com/watch?v=5rJN3vR0_1s]
seeing w brain is often called imagination.. we’re familiar w the landscapes of our imagination.. we’ve lived w them all our lives..but there are also hallucinations as well.. and hallucinations are completely diff.. they don’t seem to be of our creation.. don’t seem to be under control.. they seem to come from the outside.. and to mimic perception..
17 min – charles bonnet – wondered how the theatre of the mind could be generated by the machinery of the brain.. 250 yrs later beginning to have a glimpse how this is done