jennifer doudna

jennifer doudna

intro’d to Jennifer via wef 2016 panel… staying human

[i was intrigued when she talked of the ability to zone in on and get rid of mutations..  thinking.. great.. but won’t help.. if we don’t also get rid of mutant living.. that produced them in the first place. and perhaps in similar way..thinkings/ponderings from siddhartha et al.. placebo rna – toward a nother way to live]

A lot of what makes us human comes from our #brain chemistry: Jennifer Doudna https://t.co/VtJ9mqpBim #wef

Original Tweet: https://twitter.com/Davos/status/690908545492127748

4th industrial revolution – and what it means to be human.. and who gets to decide

8 min – hope to remove mutations from entire human species – Jennifer Doudna

10 min – tech – a place to do things that we can’t do alone – Justine Cassell – bringing back skills of 2nd revolution ie: empathy, collab, et al..

11 min  – on tech to spur us to curiosity .. in the classroom – Justine

why in the classroom?

13 min – on regulatory ness… we have to talk to each other.. who gets to decide… like davos community… great example.. of talking to each other.. Henry T. Greely… we now have power to change every single genome.. regulatory side not ready for that

perhaps getting in way and exclusive. we can do better

17 min – distinction on what to be human – and essential part of our humanity is to always extent that.. what is ness – Angela Hobbs – if staying human we need.. ie: staying curious…  then fine.. if not..  we need to have convos.. even through school years.. of what it means to be flourishing life..

so .. back to henry – and davos as an example of great convo.. but who there is talking outside of the school day/years..?

24 min – on ai saying… making autonomous machines.. like us.. but.. we are not autonomous.. we are interdependent.. – Justine Cassell

27 min – impact of computer on human beings..we have tech.. but not knowledge to know the genome yet – Jennifer

28 min  – each transition in brain – isn’t a transitor.. it’s a computer.. so complex.. – Henry… i think you’re talking.. for a full understanding of the human brain – a century or more..

so to vinay – reverse complexity

30 min – how to teach selves as human – to stick to own values – Amira Yahyaoui

31 min – when you are listened to everywhere.. doesn’t that change your life.. – Klaus Schwab

depends .. if we have ps open and something for everyone to do et al..

32 min – on it being an illusion… we’re being watched more now.. not too long ago.. many more felt watched all the time by god.. in bedroom, in soul.. i think we have more privacy now.. – Angela Hobbs

34 min – on us worrying more about someone selling us something because they read our email.. or eternal damnation.. – Justine Cassell

36 min – what’s human is not the structure.. it’s what inside – Henry – depends on how we’re taught.. it’s a process.. important that we have teachers/robots.. to teach children what it is to be human

whoa.. – perhaps we need to be learning rom 5 yr olds.. what it means to be human.. everyday. as the day.

38 min – interplay between genetics we inherit and environment we find outselves in – Jennifer

42 min – on comparison with people we don’t see as human.. that we judge what is human.. (ie: computer, women, migrants).. i’d rather that comparison go away.. and each reflects to own purpose – Justine Cassell

48 min – a lot of what makes us human comes from our brain chemistry – Jennifer

52 min – if we all create self-awareness…. – Klaus Schwab

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her sept 2015 tedglobal london:

We can now edit our DNA. But let’s do it wisely

crisper tech

when viruses infect a cell they inject their dna.. in a bacterium.. the crispr system allows that dna to be plucked out of the virus and inserted in little bits into the chromosome dna of bacterium.. these integrated bits get inserted at a site called crispr…

crispr – a mechanims that allows cells to record over time the viruses the have been exposed to… those bits of dna are passed on to the cell’s progeny…

blockchain ness

1:05 – this coordination problem

43 min – turning governance into degovernance systems is kind of radical.. but over and over again find possible once to loop… so no need for governance.. policy evaporate..

begs systemic change.. where the b ness becomes irrelevant.. what if the only governance/b we need is getting us out of the mess/mistrust/mutations/ rna ness.. we’ve accumulated over the years of ie: manufactured consent et al..

a nother way

this allows cells to keep a record of infection… a genetic vaccination card…

once bits of dna inserted into dna chromosome.. makes copy … exact replicate.. of viral rna.. a chemical cousin of dna…

little bits of rna from crispr bind to protein.. called cas9 and form a complex that functions like a sentinal.. searches to find match… when sites found… this complex associates and allows cas9 to cut up the dna..

so like a pair of scissors that can cut dna… and importantly.. this is programmable…  to make break in dna at that site…

could be harnased for genome engineering…  analogous to way we use word processing to fix typing in document

cells have ability to detect broken dna and repair it… by pasting together or integrating new…

we can trigger cells to repair breaks by disruption or incorporation of new…

crispr is like software.. can re program

clinical application w/in next 10 yrs

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find/follow Jennifer:

her lab at berkeley

http://rna.berkeley.edu/

wikipedia small

Jennifer Anne Doudna (born 19 February 1964) is a Professor of Chemistry and of Molecular and Cell Biologyat the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute(HHMI) since 1997.

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mar 2016 – crispr – removes hiv

http://futurism.com/scientists-just-removed-hiv-human-immune-cells-using-crispr-gene-editing/