adding page this day
Neuroscientists halt and reverse memory loss in 10 Alzheimer’s patients: bit.ly/2lxmsEd
Alzheimer’s is caused by the buildup of amyloid beta plaques. With a tar-like consistency, these globules gunk up the brain, choking out neurons and tearing the connections between them apart. These plaques are aided by threats of another protein called tau, which block nutrients from reaching brain cells, starving them.
Alzheimer’s disease (AD), also referred to simply as Alzheimer’s, is a chronic neurodegenerative disease that usually starts slowly and worsens over time. It is the cause of 60% to 70% of cases of dementia. The most common early symptom is difficulty in remembering recent events (short-term memory loss). As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self care, and behavioural issues. As a person’s condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to nine years.
The cause of Alzheimer’s disease is poorly understood. About 70% of the risk is believed to be genetic with many genes usually involved. Other risk factors include a history of head injuries, depression, or hypertension. The disease process is associated with plaques and tangles in the brain. A probable diagnosis is based on the history of the illness and cognitive testing with medical imaging and blood tests to rule out other possible causes. Initial symptoms are often mistaken for normal ageing. Examination of brain tissue is needed for a definite diagnosis. Mental and physical exercise, and avoiding obesity may decrease the risk of AD. There are no medications or supplements that decrease risk.
No treatments stop or reverse its progression, though some may temporarily improve symptoms. Affected people increasingly rely on others for assistance, often placing a burden on the caregiver; the pressures can include social, psychological, physical, and economic elements. Exercise programmes may be beneficial with respect to activities of daily living and can potentially improve outcomes. Treatment of behavioural problems or psychosis due to dementia with antipsychotics is common but not usually recommended due to there often being little benefit and an increased risk of early death.
In 2015, there were approximately 48 million people worldwide with AD. It most often begins in people over 65 years of age, although 4% to 5% of cases are early-onset Alzheimer’s which begin before this. It affects about 6% of people 65 years and older. In 2010, dementia resulted in about 486,000 deaths. It was first described by, and later named after, German psychiatrist and pathologist Alois Alzheimer in 1906. In developed countries, AD is one of the most financially costly diseases
Attn women: imp’t study (*by my wife) linking menopause to metabolic changes in brain that could lead to Alzheimer’s https://t.co/yJam6x2d2Q
Original Tweet: https://twitter.com/slavin_fpo/status/917839257569497088
the evidence that auguste d has not lost herself. rather, her ‘self’ was taken from her. cell by cell by cell, she had be strangled by unwelcome, malignant intruders
kafka would have enjoyed this – as a general rule, alzheimer’s sufferers must die before they can be definitively diagnosed..
earliest symptoms – short term memory loss
average interval from diagnosis to death in alzheimer’s disease is 8 yrs
you have to learn to be satisfied with what comes to you.. c.s.h.
when mind really wanders.. amazing what sort of involuntary memory leaps one makes. what’s more.. perhaps single most important point to understand about memory: every time a memory is recalled, new trails are made.. the act of remembering generates new memories.. becoming.. memory of memories.. overlap is very basis of memory and identity.. because of this, no recorded experience can ever be fully distinct from anything else..
the ease w which false memories can be implanted
recall is never replay
ready for clinical trials on humans
The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.
app to help recognize loved ones