alzheimer’sadding page this day
@bigthink Neuroscientists halt and reverse memory loss in 10 Alzheimer’s patients: bit.ly/2lxmsEd________
Around 5.4 million Americans currently live with this neurodegenerative disorder. This is the sixth most common cause of death in the U.S. By 2050, 13.8 million are projected to have it.
Alzheimer’s is caused by the buildup of amyloid beta plaques. With a tar-like consistency, these globules gunk up the brain, choking out neurons and tearing the connections between them apart. These plaques are aided by threats of another protein called tau, which block nutrients from reaching brain cells, starving them.
Alzheimer’s disease (AD), also referred to simply as Alzheimer’s, is a chronic neurodegenerative disease that usually starts slowly and worsens over time. It is the cause of 60% to 70% of cases of dementia. The most common early symptom is difficulty in remembering recent events (short-term memory loss). As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self care, and behavioural issues. As a person’s condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to nine years. The cause of Alzheimer’s disease is poorly understood. About 70% of the risk is believed to be genetic with many genes usually involved. Other risk factors include a history of head injuries, depression, or hypertension. The disease process is associated with plaques and tangles in the brain. A probable diagnosis is based on the history of the illness and cognitive testing with medical imaging and blood tests to rule out other possible causes. Initial symptoms are often mistaken for normal ageing. Examination of brain tissue is needed for a definite diagnosis. Mental and physical exercise, and avoiding obesity may decrease the risk of AD. There are no medications or supplements that decrease risk. No treatments stop or reverse its progression, though some may temporarily improve symptoms. Affected people increasingly rely on others for assistance, often placing a burden on the caregiver; the pressures can include social, psychological, physical, and economic elements. Exercise programmes may be beneficial with respect to activities of daily living and can potentially improve outcomes. Treatment of behavioural problems or psychosis due to dementia with antipsychotics is common but not usually recommended due to there often being little benefit and an increased risk of early death. In 2015, there were approximately 48 million people worldwide with AD. It most often begins in people over 65 years of age, although 4% to 5% of cases are early-onset Alzheimer’s which begin before this. It affects about 6% of people 65 years and older. In 2010, dementia resulted in about 486,000 deaths. It was first described by, and later named after, German psychiatrist and pathologist Alois Alzheimer in 1906. In developed countries, AD is one of the most financially costly diseases_______
Attn women: imp’t study (*by my wife) linking menopause to metabolic changes in brain that could lead to Alzheimer’s https://t.co/yJam6x2d2Q Original Tweet: https://twitter.com/slavin_fpo/status/917839257569497088_______ from the forgetting (2001) by David Shenk (per mention in Gabor Maté‘s scattered)
26 the evidence that auguste d has not lost herself. rather, her ‘self’ was taken from her. cell by cell by cell, she had be strangled by unwelcome, malignant intruders 35 kafka would have enjoyed this – as a general rule, alzheimer’s sufferers must die before they can be definitively diagnosed.. 36 earliest symptoms – short term memory loss 40 average interval from diagnosis to death in alzheimer’s disease is 8 yrs 43 you have to learn to be satisfied with what comes to you.. c.s.h. 55 when mind really wanders.. amazing what sort of involuntary memory leaps one makes. what’s more.. perhaps single most important point to understand about memory: every time a memory is recalled, new trails are made.. the act of remembering generates new memories.. becoming.. memory of memories.. overlap is very basis of memory and identity.. because of this, no recorded experience can ever be fully distinct from anything else.. 56 the ease w which false memories can be implantedgaslighting ness.. voluntary compliance.. manufactured consent..
recall is never replaymemory _______ ready for clinical trials on humans http://neurosciencenews.com/atp-synase-mitochondria-8291/
The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful._________ app to help recognize loved ones https://www.fastcompany.com/40519094/embargo-wed-6am-et-a-14-year-old-made-an-app-to-help-alzheimers-patients-recognize-their-loved-ones __________ towns for people w dementia
World Economic Forum (@wef) tweeted at 6:00 AM – 27 Jun 2018 : #France is building a village for people with Alzheimer’s https://t.co/5CmoQwq0pq #health https://t.co/YAvPnciiBJ (http://twitter.com/wef/status/1011942327546470400?s=17) CityLab (@CityLab) tweeted at 5:41 AM – 17 Sep 2018 : Weeks after opening near San Diego, a model town for treating dementia is set to be replicated around the United States. @amandakhurley reports: https://t.co/QsKGB4JGFA (http://twitter.com/CityLab/status/1041653306664407040?s=17) Greg Lindsay (@Greg_Lindsay) tweeted at 6:17 AM – 19 Sep 2018 : The Boomers’ final act: paying to visit strip-mall replicas of the 1950s walkable downtowns they abandoned for the suburbs, as they slip into dementia. https://t.co/RU5bIlXhUO (http://twitter.com/Greg_Lindsay/status/1042387207410135041?s=17)__________ w/o a map ___________ urea in the brain as cause to dementia https://bigthink.com/paul-ratner/scientists-discovered-what-causes-dementia ___________ fb post by mary lou
The microbiome of the brain.. not only the gut has a microbiome..the brain isn’t cordoned from other critters…just discovered recently… big changes with age. Reeling from Lisa Weiner Intrator’s awesome semi-annual conference today at MIT. Watch it all online when it’s released at www.applysci.com I learned so much about Alzheimer’s in this talk..by Rudy Tanzi from Harvard who helped discover the first 4 genes that cause Alzheimer’s.. now more than 40. He eloquently argued that it’s key to treat Alzheimer’s 20 years before it finally leads the glia to eat neurons themselves and the focused effort of so much effort in big pharma right now.__________He had great video of neurons getting eaten by glia at late stage Alzheimer’s
In a small lab in Jackson Hole, Wyo., 65-year-old Paul Cox believes he’s closing in on a treatment that might prevent Alzheimer’s disease. And ALS.http://fortune.com/longform/alzheimers-disease-cure-breakthrough/
couple modern science w indigenous knowledge (found from seeing indigenous w high occurrence while eating flying fox/bats)________
WIRED (@WIRED) tweeted at 6:02 AM – 1 Nov 2019 : Get. More. Sleep. A new study has found that our bodies clear toxins out of our brains while we sleep and could open new avenues for treating and preventing neurodegenerative diseases like Alzheimer’s. https://t.co/u5TQgkZvTu(http://twitter.com/WIRED/status/1190237734197219330?s=17)___________ on music and alzheimers
World Economic Forum (@wef) tweeted at 5:00 AM – 25 Nov 2019 : Why memories of music cannot be lost to Alzheimer’s and dementia https://t.co/AHrV1YCQUf #health #music https://t.co/rmZSsWP6Ux (http://twitter.com/wef/status/1198934435149824001?s=17)________ from gabor maté‘s myth of normal:
If you’re especially into a piece of music, your brain does something called Autonomous Sensory Meridian Response (ASMR), which feels to you like a tingling in your brain or scalp. It’s nature’s own little “buzz”, a natural reward, that is described by some as a “head orgasm”.
Turns out that ASMR is pretty special. According to a recently published study in The Journal of Prevention of Alzheimer’s Disease (catchy name!), the part of your brain responsible for ASMR doesn’t get lost to Alzheimer’s. Alzheimer’s tends to put people into layers of confusion, and the study confirms that music can sometimes actually lift people out of the Alzheimer’s haze and bring them back to (at least a semblance of) normality… if only for a short while
329caring labor.. interpretive labor.. et al
23 – society’s shock absorbers: why women have it worse334 ‘i was denying myself as a person, denying my own desires/wants.. everyone else was far more important.. ‘ that not listening to self in order to prioritize others’ needs is a significant source of the health impairing roles women assume 337 on women and emotional labor
________ _______ _________ ___________
the caretakers of alzheimer patients.. the vast majority of whom are women.. have significantly diminished immune function and poorer wound healing, suffer more respiratory illness and experience much higher rates of depression that well matched non caregiving peers..