intro’d to Thomas here (don’t remember who was rt’d by for me to see it):
Thomas N. Seyfried (@tnseyfried) tweeted at 7:54 PM – 2 Jan 2017 :
I’m quoted in this article, check it out. Cancer May Meet Its Match in Diet, Not Drugs https://t.co/wZYHtvbY9b via @bcgavel (http://twitter.com/tnseyfried/status/816115473582428160?s=17)
talk on his book – mar 2015: Cancer: A Metabolic Disease With Metabolic Solutions
data for cancer death stats.. sobering numbers.. but people look into them and see sign advance.. increase in deaths per year.. not as fast as number of new cases.. so based on that.. say we’re winning war on cancer.. 1600/day dying from cancer.. can you imagine if we had 1500 people dying a day to ebola.. but in cancer. . kind of accepted.. just way it is.. ..i think there has to be a change here.. we’re spending bn’s of dollars on this disease.. and seeing increase in incidence and deaths per day.. why is this..
my view – we have misunderstood what the nature of the disease is..
nuclear genetic or metabolic? the answer will change way we study/manage disease..
3 min – today .. academic and pharm view cancer as genetic disease.. this is what we call the dogma.. an unshakeable belief… it’s in all the textbooks.. our young people are studying cancer as a genetic disease.. it’s the fundamental basis for the pharma/academic industries for their grants.. et al .. is that right..?
5 min – according to dogma.. it’s a combo of.. here’s a normal cell.. chromosomes and on those chromosomes are genes.. and then all of a sudden you get a somatic mutation.. and more and few more.. and all of a sudden this cell becomes a malignant cell.. and then you have to use all kinds of treatments
7 min – departments so we can screen all the (1000s of hodgepodge) of mutations.. in the tumor cells.. to develop very expensive drugs that often don’t work very well and can harm you.. and yet we’re going forward.. immuno therapies.. all this kind of stuff..
evidence that challenges the somatic mutation theory of cancer… you mean to tell me there’s no evidence..? everybody has bought on to this..?.. why no one challenges..? why no one talks about the articles that don’t support that.. then shows ie’s of paper from 69… on frogs;.. on mice.. conclusion.. that somatic mutations can’t be responsible.. structural mutations in genome can’t explain this;.. then another more recent .. mouse…. again.. not causing tumors.. but aborting..; another mice from melanoma cells..(10 min).. finds same mutations in mouse that was present in melanoma.. but no tumors;.. more recent.. transfer non cancerous mitocondria.. can completely shift cancer phenotype..by moving mitocondria around..
11 min – these findings are incompatible..w somatic mutation theory of cancer ..only a snapshot of many many studies i pulled together for the first time.. and when you see these together for first time.. you wonder.. do the people who run the genome projects know about this.. well.. often times they ignore it .. they don’t discuss this
12 min – normal cells beget normal.. tumor beget tumor.. what is responsible for this disregulated growth.. is it mutations in nucleus (as dogma suggests).. or something to do with abnormalities in mitochondria..?
what’s happening is that the normal mitochondria.. can suppress the formation of tumors.. and whatever the gene mutations happen to be.. they’re not the drivers of this disease.. yet we’re focusing on that..
13 min – if somatic mutations are not the origin.. where does cancer come from.. how do cancer cells arise.. how do we get cancer..
(otto) warburg had it pegged a long time ago in germany.. one of leading biochemists of the 20th cent:
warburg theory of cancer
1\ cancer arises from damage to cellular respiration
2\ energy through fermentation gradually compensates for insufficient respiration
3\ cancer cells continue to ferment lactate in the presence of oxygen (warburg effect)
4\ enhanced fermentation is the signature metabolic malady of all cancer cells
if you hold your breath.. your cells begin to ferment.. you breathe.. and get rid of lactic acid.. cancer cells continue to produce lactic acid even when oxygen is present..something’s wrong here.. problem with respiration..
14 min – every cancer cell has diff kinds of mutations.. but they all ferment.. why are we not focused on their abnormality that’s common to all the cells.. rather than on the defects that’s present only in a few of them..
15 min – common diff between cancer cell and normal cell
16 min – the cell to survive must ferment.. and that’s what these cancer cells are doing.. they’re all fermenters.. paper: no none cancer cell that doesn’t have some defect in the structure of these little organelles
we’re trying to show all.. the observations that we see in cancer.. based on a metabolic underpin.. trying to show that if hypothesis/theory is correct.. you should be able to explain vast changes in disease.. which we can..
17 min – how can we have so many provocative agents in environment cause disease thru common mech.. ie: gene..et al.. we can show all linked to their damaging the organelle.. all agents will do that.. viruses.. age.. organelle gets damaged with age..
18 min – when organelle is damaged it produces these reactive oxygen species.. toxic by products of energy metabolism..and these ros are both carcenogenic and mutagenic.. they will damage the dna in the nucleus and they will further damage the energy metabolism in the mitochondria…. so these little ros are produced from this plethera.. some people say – i don’t know how i got cancer.. it could be from any one of these things damaging that.. producing these ros.. the ros then damage the dna..
so all the mutations and broken down chromosomes and all these things that we see and are studying and we’re spending bns of dollars on .. are downstream epi-phenom of the damage to the respiration…
via warburg: as respiration gets damaged from a chronic inflamatory.. from smoking.. from carcenogens.. or whatever.. respiration in the cell goes down… and the cell to survive must begin the fermentation.. the cells are compensating.. they are respirating for the primitive form of energy that existed on the planet before oxygen.. which is fermentation..
19 min – what’s driving this..? the oncogenes..these things that we’re all focusing on .. mitochondria signal the nucleus.. we are insufficient with respiration.. we’re going to die if we don’t get help.. signal goes to nucleus.. oncogenes turn on.. oncogenes are transcription factors that increse fermenation energy pathways.. so .. a knee jerk response to the damage of that organelle.. now you go back and put all the pieces of the hallmarks of cancer together. .. linked to the damage of that one organelle..
20 min – it can all be linked back to this one common factor.. damage to the respiration..
warburg: if you damage respiration too acutely.. cell dies it can never become a cancer cell .. but what we have here is avoidance of a metosis.. and then you have this metastatic issue.. of our immune cells fuse with these tumor cells and then you have metastasis because these cells naturally spread throughout the body
if all cancers are a type of mitochondrial metabolic disease.. then what therapies might be effective for managing tumors.. calorie restriction.. diff from starvation studies..
21 min – slide..
if you stop eating.. the mitochondria break down.. and say.. this mitochondria is not working.. get rid of him..
basal metabolic rate of mouse is 7x faster than that of human.. they eat 25% of body weight a day.. humans are much more capable of dealing with these metabolic shifts than the mouse..
22 min – when we stop eating.. blood sugar goes down.. the brain needs sugar.. should be unconscious.. so what happens.. because.. insulin goes down glucocon goes up.. and then you start mobilizing the fats after a couple of 36 hours.. get rid of the glycogen.. and we take the fats.. and it goes to the liver .. and the liver breaks it up.. like putting logs of fatty acid into a wood chipper.. out come these water soluable ketone bodies.. and they go to the brain.. and the brain will burn ketone and glucose.. so the ketones take pressure off the fact that you’re lowering blood sugar.. this is an evolutionary conserved adaptation to starvation.. otherwise we’d been wiped out as a species.. humans have evolved to starve..
23 min – starvation is a pathological state.. a period when therapeutic fasting moves to starvation..which is pathologal.. and that’s very dangerous.. you have to be very careful about this..
diagram explaining how this might work to kill tumor cells or at least arrest their disregulated proliferation..
24 min – waste lactid creates an acidic micro environment.. cells can’t effectively respire.. lower fuels.. bring in ketones.. go right into mitochondria.. problem: tumor cells have all these defects .. they can’t use the ketones…. the normal cells burning ketones because evolved to do that.. tumor cells staggering/stumbling.. this is a fuel they can’t use because they’re mitochondria defective.. so we metabolically marginalize these cells.. kills a lot of them.. doesn’t kill them all.. but it slows the whole process..
25 min – as glucose goes down.. ketones go up.. tumors size goes down
many people have now shown this in diff kinds of tumors.. brain cancer linked to blood sugar.. it doesn’t mean the blood sugar causes the cancer.. but if you have the blood sugar.. the tumor will grow faster with the higher blood sugar..
higher blood sugar faster tumor is going to grow.. because it’s going to ferment the sugar.. prime fuel for fermentation..
people say.. what’s the mechanism.. we showed the mechanism.. ie: slide: anti-tumor effects of calorie restriction: 1\ anti angiogenic (mukherjee) 2\ anti-inflammatory (mulrooney) 3\ pro-apoptotic (mukherjee)
on last slide.. see that it’s actually purna.. any relation..?
26 min – you want them to die by own self suicide.. apotosis.. don’t want to kill everybody.. this kills thru pro apoptotic mech which is really nice..
27 min – the probelm with calorie restriction is.. it’s calorie restriction.. people with cancer under a lot of mental stress.. now tell them.. going to have to stop eating for like 3 wks.. .. so what we do .. we can achieve same kinds of metabolic manipulation with these ketogenic diets....a lot of controversy on what a ketogenic diet is.. come in all sizes/shapes and got to be careful.. basically.. a low carbo diet.. high fat.. moderate protein.. a lot of energy per gram of food (slide)
29 min – people say.. how are you eating low carb diet.. where’s the sugar coming from.. it’s coming from the liver.. if eat too much fat get dislipodemia.. insulin insensitivity.. and the blood sugar stays high.. once blood sugar goes down.. ketones go up… normally pee out ketones as fast as you make them.. but if restrict diet.. they stay in the bloodstream in much higher concentration.. and if you get ketones high enough.. they will absolutely kill the tumor cells.. pharma selling expensive to do same..
ketones up .. blood sugars down.. and get into this zone of metabolic management..
30 min – dog story.. vet said.. going to have to have surgery and chemo.. going to be expensive and only going to live 6 mos.. she did diet and tumor gone.. dog fine..
31 min – can’t use this therapy in our clinic.. don’t believe in feeding dogs raw meat.. (was part of diet she gave dog)..
we’re up against a mindset here
there are people who are aware of this.. and are working on it with dogs..
what about people.. linda nebling at nih.. two little girls.. they had gavin toxic drugs.. sad.. radiated.. surgically mutalated.. then she put them on this diet.. quality of lives came back.. didn’t survive..
34 min – what do we do to people who have brain cancer.. i published a paper.. so pissed off.. never thought anybody would accept it.. but it got published (slide).. two prime tools needed to survive.. provided by standard of care .. this is the perfect storm of adverse affects.. look at survival of standard of care.. if you look at this trial.. nobody survived..
37 min – why patients living longer when you give them the drug that increase these mutations..?
we’ve come up with this press pulse paradigm – a novel theraputic strategy for the metabolic management of cancer.. thinking this is a more rational way to deal with this cancer..
38 min – a mild metabolic stress that makes these tumor cells vulnerable.. (normal cells have evolved to survive this stress.. but not mutated ones) .. then we come in with non toxic drugs and we hit em..
39 min – when we combine certain diets with the press we get non toxic synergy
we don’t all right ways/dosage.. but we think we can perfect all that.. 25% of all cancer deaths come from some mesatisis to the brain
40 min – problem.. if have cancer.. don’t know when you’re in this metabolic zone.. so .. developed indicator.. glucose/ketone=gki.. like diabetic checking blood sugar level.. a tool to assess their therapeutic efficacy..
41 min – not only for brain tumors.. but a number of chronic diseases.. like alzheimers.. parkinsons.. traumatic brain injury.. they reduce inflammation.. provide alt fuel to brain..
42 min – conclusion.. non-toxic approaches: 1\ restricted ketogenic diet (r-kd) 2\ r-kd combined with press pulse paradigm…. i can’t tell you it’s going to work to solve cancer problem.. but i can tell you.. i think it works.. and it’s not going to hurt you
43 min – q&a
45 min – been having my students try to disprove this.. and they haven’t yet.. and it’s not that you can’t.. there are people who have their whole livelihood wrapped up in this theory.. they’re not going to change their minds if salary depends on this.. we can go with flow .. huge cost.. but numbers not changing.. oh it’s coming.. hope hope hope.. i see it differently.. i see something that might work and is not harmful.. they say.. ketogenic diet is harmful.. compared to what..?
telling audience.. you can talk to dom
51 min – atkins has too much protein in it..
53 min – you don’t get cancer unless you damage your mitochondria.. and these people under these fasting conditions have low glucose and high ketone.. they’re in that zone.. very few people on the planet can do that.. you gotta be like somebody different.. you have to be extremists.. (fasting) .. and you’re right.. they don’t have cancer (early ages – hundreds of yrs ago – when they fasted more) .. all this came when they changed the food and drug admin labels in early 80s and we get all this high fructose corn syrup into the food chain.. and now we’re getting body inflammation.. all these chronic diseases..all related to the same thing… so now how do you prevent.. prevention is a diff issue.. big section in my book on prevention.. nobody cares.. i mean people care when they get cancer.. you can prevent.. but you have to change your thinking.. and the food industry doesn’t help us.. we’re not using natural stuff here.. people are on the run all the time.. don’t have time to sit down.. and we’re putting ourselves at risk.. it’s us.. it’s the food industry and us..
Author of Cancer as a Metabolic Disease. Boston College professor.
#cancer will be managed with metabolic therapies.
boston college page (lucky there’s lots there.. because no wikipedia page on him)
Fields of Interest
Ganglioside Storage Diseases
Dietary Energy Restriction
Our research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets. Our approach is based on the idea that compensatory metabolic pathways are capable of modifying the pathogenesis of complex diseases. Global shifts in metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells. The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry.
Dr. Seyfried published a groundbreaking treatise entitled, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012). The treatise provides extensive information showing that cancer can be best defined as a mitochondrial metabolic disease rather than as a genetic disease. This new concept has implications for the development of new non-toxic cancer therapies including the ketogenic diet. Experts in the cancer research field have praised this comprehensive study as one of science’s hottest topics
fasting for 3 days:
The researchers say fasting “flips a regenerative switch” which prompts stem cells to create brand new white blood cells, essentially regenerating the entire immune system.
doc – 2010 – cancer: the forbidden cures